Xanthine derivatives have been used in allergic asthma for their bronchodilatory and anti-inflammatory properties; however, these agents have multiple side effects. Several stimulants are derived from xanthine, including caffeine, theophyline, and theobromine. Bioavailability: ~100% (monotherapy) Peak plasma time: 1-4 hr (single dose) Name Xanthine derivatives Accession Number DBCAT001034 (DBCAT000503, DBCAT001028, DBCAT001220, DBCAT002203, DBCAT002692, DBCAT003295) Description. Classifications of bronchodilators include beta 2-agonists, anticholinergics, and xanthine derivatives. Among the xanthine derivatives the rank order of potency was enprofylline greater than theophylline greater than caffeine greater than theobromine greater than xanthine greater than TMX. Chemical Products . Xanthine (/ ˈ z æ n θ iː n / or / ˈ z æ n θ aɪ n /; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most human body tissues and fluids and in other organisms. This list contains the names of many medical problems and the names of drugs that may be used for their treatment. These agents are used as additional therapy for patients who remain in refractory status asthmaticus despite maximal inhalational therapy … These medications open the airways, but they work on different receptors in … Absorption Lesinurad. The drugs are listed either as a generic name or drug class name. Traditional asthma medications such as theophylline have less of a role in the treatment of pure exercise-induced asthma. 5. Allopurinol: Xanthine oxidase inhibitor that inhibits conversion of hypoxanthine to xanthine to uric acid; decreases production of uric acid without disrupting synthesis of vital purines. We have included drug actions … 5.7 Xanthine derivatives. Fortunately, generic names tend to follow patterns, with prefixes and suffixes often determining the class of medication. It is worth noting that members of this series lack the carboxylic acid to interact with Arg111 of GPR109A, unlike compounds in the aforementioned series. Cardiac adverse effects include sinus tachycardia, extrasystole, palpitations, and … The Chicago-based women name about 200 generic drugs per year, and the naming process is very scientific … sometimes. Chemistry; End Use; Value Chain Xanthine Derivatives. A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. In addition, gastroesophageal reflux has been observed to occur during sleep in patients taking these drugs. A xanthine series (I) exemplified by 33 and 34 is another important class of GPR109A agonists [83–88]. 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