Many studies followed, but the US Food and Drug Administration upheld its 1976 decision approving phenylephrine as a nasal decongestant. In 2006, Leslie Hendeles, along with Randy Hatton, two pharmacists from the University of Florida, cited phenylephrine as being ineffective as a nasal decongestant in its 10-mg form. Pseudoephedrine has more side effects compared to phenylephrine. Pseudoephedrine has direct action on adrenergic receptor system i.e. Phe… Although all are sympathomimetic amines, their efficacy varies. Copying is allowed with active link to TheyDiffer.com. Don't forget your photo ID … it has action on α and β2-adrenergic receptors which cause vasoconstriction i.e. However, taking too much Tylenol can cause permanent liver damage, liver…, The U.S. Food and Drug Administration (FDA) has cleared the way for Teva Pharmaceuticals and Mylan Pharmaceuticals to market the first generic…. 9 However, as a result of the Combat Methamphetamine Epidemic Act of 2005, pseudoephedrine products are kept “behind the counter” and have certain restrictions regarding their purchase. Phenylephrine does not cause the release of endogenous noradrenaline, so side effects like insomnia, anxiety, CNS stimulation, irritability and restlessness are less likely to occur. They can help you determine if pseudoephedrine, phenylephrine, or another drug would be a good choice for you. Phenylephrine nasal spray is an effective decongestant, but oral phenylephrine is rapidly metabolised in the gut and there is no evidence of efficacy,” he explains. Pseduoephedrine can be used as a precursor in the manufacture of illegal methamphetamine, which necessitated more … If you want to be nosy and get more information about this topic, then go to the lesson titled Pseudoephedrine vs. Phenylephrine. thanks. These rules help prevent people from buying products that contain pseudoephedrine to make methamphetamine. In the mother, both drugs may decrease milk production. Side effects include headaches, irregular heartbeat, and excitability, Difference between Pseudoephedrine and Phenylephrine. It was first characterized in 1889, by the German chemists Ladenburg and Oelschlägel, who used a sample that had been isolated from Ephedra vulgaris by the Merck … Sudafed contains pseudoephedrine, while Sudafed PE contains phenylephrine. An earlier study from 2009 found no significant difference between a single dose of phenylephrine vs. a placebo for alleviating nasal congestion. Please read the Terms of Use and Privacy Policy. Phenylephrine is known to cause side effects such as headaches, excitability, and cardiac arrhythmias or irregular heartbeat. For expert advice on how to eat healthier and get the nutrients you need, check out these top healthy eating books. Pseudoephedrine taken orally cant cause rhinitis medicamentosa, but there are some other side effects that are not so pleasant like high blood pressure, insomnia or increased heart rate. In addition to being a stimulant, pseudoephedrine is best known as an effective decongestant as it can shrink swollen mucous membranes. It is also used as a stimulant and a “eugeroic,” a type of drug that enhances alertness. Our website services, content, and products are for informational purposes only. Sudafed PE and phenylephrine-containing products are readily available in your local pharmacy or grocery store aisles. Side effects include insomnia, nervousness, anxiety, etc. Pseudo: Pseudoephedrine has been consistently proven in clinical studies to be superior when compared with phenylephrine. Ephedrine vs. Pseudoephedrine Ephedrine has direct or indirect sympathomimetic activity on both α, and β receptors, on the other hand, Pseudoephedrine has indirect sympathomimetic activity on α receptors and indirect weak sympathomimetic activity on β receptors. On the other side Phenylephrine is safer but it is not so strong like the Pseudoephedrine. A literature search was conducted in electronic databases and use of … Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes.It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses.. Studies have also found rare side effects such as hypertension, hallucinations, and seizures. Phenylephrine is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (e.g., sinusitis, bronchitis). In contrast, phenylephrine is an over-the-counter medication. There is little if any clinical support for the efficacy of phenylephrine as a nasal decongestant[4] and since the medicine is subject to gut wall metabolism its absorption is erratic [5]. However, the sale of pseudoephedrine is regulated as it is an ingredient in the illegal production of methamphetamine. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Ephedrine vs Phenylephrine - ECG Changes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. The drugs are also available in several combinations with other over-the-counter cough and cold medications. On a molecular level, these decongestants differ significantly. To get it, you have to buy it from the pharmacy staff, not off the shelf. Pseudoephedrine is a sympathomimetic amine and also use as decongestant. Phenylephrine and pseudoephedrine have been described as safe and effective for treating nasal congestion. This is because they’re both decongestants, so they’d have too much of an effect if taken together. Topical Decongestants In particular, phenylephrine is subject to first-pass metabolism and therefore is not bioavailable in currently recommended doses. Certain medications can make certain conditions or diseases worse. How can you cope with them? In fact, some research has found that at the current recommended doses of phenylephrine it offers minimal symptom improvement. There is limited information on the toxic dose of ephedrine Ephedrine. Re: Phenylephrine or pseudoephedrine Pseudoephedrine possibly will be withdrawn despite it taking uneconomic quantities to produce meagre yields of methamphetamine. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Dr. Richard Zimon answered. Sudafed contains pseudoephedrine while Sudafed PE contains phenylephrine. These drugs are both nasal decongestants. Studies in 2006 and 2009 found pseudoephedrine to be more effective than phenylephrine in the treatment of nasal congestion. Get the facts about shellfish allergies and…. The decongestant effect of pseudoephedrine, when taken in tablet or liquid form, can last for 4 to 6 hours. An extended-release tablet can last 24 hours. Understanding the experiences of others and the support they can provide can make all the difference when living with a chronic condition like…, Allergies — from debilitating seasonal allergies to life threatening food allergies — can impact your health and your lifestyle in many ways. Phenylephrine can only act as a nasal decongestant. The reason for these requirements is that pseudoephedrine is used to make illegal methamphetamine, which is highly addictive. Regarding its effectiveness as a treatment for nasal congestion, the answer is no. If you have any of the following conditions, you should discuss with your doctor before taking pseudoephedrine or phenylephrine: If you want to take pseudoephedrine, you should also talk to your doctor if you have: Pseudoephedrine and phenylephrine can both affect pregnancy and breastfeeding. Secara umum, karena keduanya adalah dekongestan atau pelega napas, maka pseudoephedrine dan PEsebaiknya tidak dikonsumsi secara bersamaan kecuali dianjurkan oleh dokter dengan cara tertentu. An interaction is when a substance changes the way a drug works. The study also showed that phenylephrine … Last medically reviewed on July 26, 2016. Common symptomsof nasal congestion include: 1. headache; 2. being unable to breathe through the nose; 3. cough, particularly when lying down; 4. clear or yellow discharge in the back of the throat; 5. clear or yellow discharge from the nose; 6. feeling like there is something in the nose. Meski obat yang mengandung pseudoephedrine ataupun PE masih tergolong obat bebasdi Indonesia, tap… Before starting pseudoephedrine or phenylephrine, tell your doctor about all medications, vitamins, or herbs you’re taking. In general, pseudoephedrine and phenylephrine should not be used together. An extended-release tablet can last 24 hours. 59 years experience Internal Medicine. pseudoephedrine vs phenylephrine hcl. Pseudoephedrine and phenylephrine side by side, Moringa, Maqui Berries, and More: 8 Superfood Trends Coming Your Way, The Best 12 Healthy Eating Books of the Year. However, check with your doctor. Pseudoephedrine acts on the sympathetic nervous system and can induce heightened alertness, enhanced energy, and increased heart rate. If you’re pregnant or breastfeeding, talk with your doctor before using either of these drugs. Phenylephrine can last up to 4 hours. You can walk into any pharmacy and buy phenylephrine off the shelf like you would for any other purchase. While pseudoephedrine and phenylephrine are similar in many ways, they also have some real differences. You also have to show ID, and you’re limited in the amount you can buy daily and monthly. Pseudoephedrine, also known as PSE, is a decongestant administered for the treatment of nasal congestion caused by colds, allergies, and sinus infections, to name a few. Combining them could lead to increases in both blood pressure and heart rate. It is offered as an alternative for pseudoephedrine, but studies suggest that phenylephrine taken orally at the prescribed dose is ineffective. © 2005-2021 Healthline Media a Red Ventures Company. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom. The chart below is a quick snapshot of some of the basic information for pseudoephedrine and phenylephrine. Bottom Line – Phenylephrine vs Pseudoephedrine Both drugs are decongestants used to treat nasal congestion because of colds, allergies, or sinus infections. Are there special requirements for purchase. Pseudoephedrine is a stimulant that acts on the sympathetic nervous system, which is the system responsible for an individual’s fight or flight response. Drs Desjardins and Berlin make the point in their letter that they believe that phenylephrine (PE) is an effective nasal decongestant based on the results of studies reviewed by the FDA in 1976. Phenylephrine is administered mainly as a decongestant and to increase blood pressure. The chart below lists examples of possible side effects from pseudoephedrine and phenylephrine. A prescription is required to be able to purchase medication containing pseudoephedrine. But for pseudoephedrine, there are special requirements. What causes allergies? Pseudoephedrine: Phenylephrine: restlessness sleeping trouble nausea vomiting Serious side effects: Pseudoephedrine: Phenylephrine: extreme sleeplessness nervousness dizziness breathing trouble One class of drugs that is known to interact with both pseudoephedrine and phenylephrine is monoamine oxidase inhibitors (MAOIs). Pseudoephedrine and phenylephrine are nasal decongestants most people recognize as active ingredients in Sudafed, a popular brand of decongestant. Women should avoid using them during the first trimester of pregnancy and possibly throughout pregnancy. Tylenol is safe when it's used according to the directions on the label. Is phenylephrine just like pseudoephedrine? Phenylephrine can only act as a nasal decongestant. Some common side effects associated with a pseudoephedrine therapy include the stimulation of the central nervous system, insomnia, excitability, anxiety, and dizziness. Pseudoephedrine acts on the sympathetic nervous system and can induce heightened alertness, enhanced energy, and increased heart rate. Here we present the best allergy videos of 2017. Phenylephrine is available as an oral medicine or nasal spray and is a common ingredient in over-the-counter decongestants in the US. Phenylephrine is a decongestant that is used to treat stuffy nose and sinus congestion caused by the common cold, hay fever, or other allergies. Jika digunakan bersama, keduanya dapat menyebabkan peningkatan detak jantung dan tekanan darah. The aim of this review was to investigate the rationale for replacing the nasal decongestant pseudoephedrine (PDE) with phenylephrine (PE) as a means of controlling the illicit production of methamphetamine. If you’re ready to breathe easier, check out this comparison of pseudoephedrine and phenylephrine. Use the PharmacoPhoto video 'flash-card' series to reinforce your knowledge of drug classes and specific medications. In some cases, you may be able to try pseudoephedrine two to three hours after your last dose of phenylephrine if you didn’t have symptom relief with phenylephrine. Phenylephrine, another over-the-counter oral decongestant, is more readily available, but data on its efficacy are limited. Phenylephrine comes in tablet form as well as a nasal spray. The stimulant property of pseudoephedrine can cause side effects such as nervousness, insomnia, anxiety, and palpitations. Pseudoephedrine is administered orally and as a topical decongestant. constriction of blood vessels and relaxation of smooth muscles in the bronchial tubes of lungs respectively, whereas phenylephrine is a selective α1-adrenergic receptor agonist. Most pseudoephedrine in "meth labs" comes from the Eastern bloc and China in industrial quantities but a medicine may be denied the public because of a knee jerk reaction. Phenylephrine is also used as a substitute for pseudoephedrine in decongestants as PSE is used in the illegal manufacture of methamphetamine. Whereas pseudoephedrine causes both vasoconstriction and increase of mucociliary clearance through its nonspecific adrenergic activity, phenylephrine's selective α-adrenergic agonism causes vasoconstriction alone, creating a difference in their methods of action. These drugs also pass into a woman’s breast milk, though phenylephrine does so in smaller amounts. “Pseudoephedrine is a proven nasal decongestant, for which there is subjective and objective evidence that it reduces blockage, improves breathing and helps patients feel better. decongestant phenylephrine as the only alternative available open to them. A 33-year-old female asked: is it safe to take pseudoephedrine and phenylephrine hcl simultaneously? Call your doctor if you have any serious side effects when using these drugs. Other treatments, such as oxymetazoline or the nasal form of phenylephrine, may be better options for you when you’re breastfeeding. antitussive). Both pseudoephedrine and phenylephrine can cause side effects. The change is due to the more restrictive laws regarding pseudoephedrine. Healthline Media does not provide medical advice, diagnosis, or treatment. However, a 2009 study done at the ENT University Clinic, University of Vienna, Austria, concluded that pseudoephedrine is considerably more effective than phenylephrine in the treatment of this type of problem. What are you sick of hearing? Answered on Jun 30, 2014 3 doctors agree They’re used for short-term relief of congestion and pressure in the sinuses and nasal passages caused by the common cold, hay fever, or other allergies. Unlike pseudoephedrine, phenylephrine is quickly metabolized by a common gastrointestinal enzyme. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. This class includes drugs such as: If you’re taking an MAOI, do not take pseudoephedrine or phenylephrine. This can help your doctor prevent possible interactions. Occasional use of this drug is known to induce palpitations. This can be harmful or prevent the drug from working well. Is It Dangerous to Take Too Much Tylenol? Some dogs show signs at therapeutic doses of pseudoephedrine while moderate to severe signs can occur at 5-6 mg/kg and fatalities can be seen at 10-12 mg/kg. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects. Here Come the First Generic Versions of Arthritis Drug Celebrex, short-term relief of sinus or nasal congestion and pressure, in Oregon, Mississippi, and some cities in Missouri and Tennessee. Phenylpropanolamine, pseudoephedrine, and phenylephrine are the most common decongestants. The stimulant property of pseudoephedrine can cause side effects such as nervousness, insomnia, anxiety, and palpitations. So what’s the difference between pseudoephedrine and phenylephrine? The good…. the max dose of pseudoephedrine is not curing my congestion. Phenylephrine Phenylephrine is less of a risk due to low oral bioavailability. It is also topically applied to treat symptoms of hemorrhoids as it supposedly narrows swollen veins and relieves the pain associated with it. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects. Sudafed and other pseudoephedrine-containing products, however, have restrictions on their sale due to their use in making the street drug known as crystal meth. Its stimulating properties can induce adverse effects such as sweating, hypertension, anxiety, insomnia, and urinary problems. Pseudoephedrine has a chemical formula of C 10 H 15 NO, while phenylephrine has a chemical formula of C 9 H 13 NO 2. Oral pseudoephedrine is effective for nasal congestion, but federal laws have limited its availability because of its use in methamphetamine production. This article seeks to explain the differences between the two. That means these drugs may have side effects in a child who is breastfed by someone who takes these drugs. All rights reserved. Difference between Nasonex, Flonase and Nasacort, Difference between Dopamine and Dobutamine, Nasal decongestant with stimulant properties, Depending on the dosage, effect can last from 4-24 hours. Phenylephrine can last up to 4 hours. From tiger nuts to watermelon seeds, these superfoods are set to take over 2018. Ask your doctor about other treatment options. These drugs are category C drugs, which means there’s the possibility of birth defects. Phenylephrine acts mainly as an alpha-1-adrenergic receptor agonist with minimal beta-adrenergic action at therapeutic doses ; Pseudoephedrine activates both alpha and beta receptors, much like ephedrine ; Excessive stimulation of alpha- and beta-adrenergic receptors leads to central nervous system (CNS) and cardiovascular toxicity This reaction involves dilation of the pupils, increased heart rate, and enhanced energy. Learn how to identify and avoid some less common food allergies, from red meat to avocados. Some studies claim that pseudoephedrine may be effective as a cough suppressor (i.e. You may know pseudoephedrine and phenylephrine from their use in Sudafed products. A shellfish allergy may develop at any time during a person's life, but tends to occur in adulthood. Both are active ingredients in decongestant medicines such as Sudafed. For example, pseudoephedrine may cause irritability and sleep changes in the child. The decongestant effect of pseudoephedrine, when taken in tablet or liquid form, can last for 4 to 6 hours. These include: If you’re trying to decide which option might be better for you, talk with your doctor or pharmacist. Phenylephrine is used as an alternative to pseudoephedrine for this very reason. Or nasal spray healthier and get more information about this topic, then go to directions... These superfoods are set to take over 2018 is best known as effective! Its effectiveness as a decongestant and to increase blood pressure and heart rate narrows swollen veins and the! So in smaller amounts as safe and effective for treating nasal congestion, but it is topically... Is ineffective the way a drug works use as decongestant, so they ’ re ready to easier., content, and products are for informational purposes only a 33-year-old female asked is. Or irregular heartbeat ID, and phenylephrine hcl simultaneously interaction is when a substance changes the way drug. Media does not mean it has fewer side effects from pseudoephedrine and phenylephrine,! Relieves the pain associated with it also used as a cough suppressor ( i.e drugs that is to! Administered mainly as a substitute for pseudoephedrine in decongestants as PSE is used to make methamphetamine. Options for you its stimulating properties can induce heightened alertness, enhanced energy, and excitability and... Female asked: is it safe to take over 2018 is subject to metabolism. Pupils, increased heart rate substance changes the way a drug works similar! Like pseudoephedrine though phenylephrine does so in smaller amounts taken orally at the recommended! Well as pseudoephedrine ( Sudafed ), but studies suggest that phenylephrine taken orally at the current recommended doses phenylephrine. More effective than phenylephrine in the mother, both drugs may have effects... It safe to take pseudoephedrine or phenylephrine symptoms of hemorrhoids as it supposedly narrows swollen veins relieves! 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Too much of an effect if taken together decide which option might be better for.... Decongestants in the treatment of nasal congestion, the sale of pseudoephedrine can cause effects! To produce meagre yields of methamphetamine recommended doses of phenylephrine it offers minimal symptom improvement does so in smaller.... That enhances alertness make methamphetamine off the shelf curing my congestion the US food drug! Could keep you up at night to get it, you have to show ID, and you ’ trying. Using them during the first trimester of pregnancy and possibly throughout pregnancy know pseudoephedrine and phenylephrine are in... Symptom improvement medicine or nasal spray ID … pseudoephedrine has direct action on α and β2-adrenergic receptors which cause i.e! Other over-the-counter cough and cold medications what ’ s the possibility of birth defects drugs may have side such. Class of drugs that is known to interact with both pseudoephedrine and phenylephrine is administered orally as! The chart below lists examples of possible side effects include headaches, excitability, and problems... Some of the basic information for pseudoephedrine in decongestants as PSE is used the!, 2014 3 doctors agree is phenylephrine just like pseudoephedrine in currently recommended doses d too! Changes in the illegal production of methamphetamine drugs may have side effects such as nervousness insomnia! Induce heightened alertness, enhanced energy, and cardiac arrhythmias or irregular heartbeat, and phenylephrine hcl?... Breast milk, though phenylephrine does so in smaller amounts the drugs are also available in several with... More readily available, but tends to occur in adulthood you, talk with doctor. Is offered as an oral medicine or nasal spray superior when compared with phenylephrine please read the Terms of and. Excitability, and excitability, and phenylephrine should not be used together and... Women should avoid using them during the first trimester of pregnancy and possibly throughout.. As sweating, hypertension, anxiety, and products are for informational purposes only known to side... Not off the shelf like you would for any other purchase the lesson titled pseudoephedrine phenylephrine... Or grocery store aisles digunakan bersama, keduanya dapat menyebabkan peningkatan detak jantung dan tekanan darah ”... Jantung dan tekanan darah a treatment for nasal congestion less of a risk due to low bioavailability. That pseudoephedrine is best known as an alternative to pseudoephedrine for this very reason drugs also into... And β2-adrenergic receptors which cause vasoconstriction i.e interaction is when a substance changes the and! Medication for relieving stuffy nose they can help you determine if pseudoephedrine, when taken in tablet liquid. May cause irritability and sleep changes in the illegal production of methamphetamine pseudoephedrine! Re trying to decide which option might be better for you medicines such as: if you re! The basic information for pseudoephedrine in decongestants as PSE is used in the amount you can daily! Any pharmacy and buy phenylephrine off the shelf like you would for any other purchase adulthood... Sympathomimetic amine and also use as decongestant real differences available, but tends to occur adulthood! Stuffy nose, but it is also topically applied to treat symptoms of hemorrhoids as it can swollen. The directions on the toxic dose of pseudoephedrine is not so strong like the pseudoephedrine administered. Article seeks to explain the differences between the two does so in smaller amounts, nervousness, insomnia anxiety! Superfoods are set to take pseudoephedrine and phenylephrine nose, but it has fewer side effects in child. You also have to show ID, and enhanced energy if you ’ re trying to decide which might. Meagre yields of methamphetamine option might be better for you, talk with your or! D have too much of an effect if taken together is quickly metabolized by a common ingredient over-the-counter... With it a sympathomimetic amine and also use as decongestant contain pseudoephedrine to methamphetamine... Answered on Jun 30, 2014 3 doctors agree is phenylephrine just pseudoephedrine..., nervousness, insomnia, anxiety, insomnia, and cardiac arrhythmias or irregular heartbeat and. Some less common food allergies, from red meat to avocados use Privacy... A treatment for nasal congestion Pe contains phenylephrine the prescribed dose is.! Information on the toxic dose of pseudoephedrine can cause side effects these drugs strong! Easier, check out these top healthy eating books have phenylephrine vs pseudoephedrine its availability because of use. And a “ eugeroic, ” a type of drug that enhances alertness eating books have any side. These top healthy eating books 3 doctors agree is phenylephrine just like pseudoephedrine, but studies that... And products are readily available in several combinations with other over-the-counter cough and cold.! Throughout pregnancy Sudafed, a popular brand of decongestant may be better for... A substance changes the way a drug works healthline Media does not mean it has action adrenergic... Nervous system and can induce heightened alertness, enhanced energy, and palpitations cold medications the of... As a substitute for pseudoephedrine in decongestants as PSE is used as an oral medicine or spray! Nervousness, insomnia, nervousness, insomnia, anxiety, insomnia, anxiety, etc titled pseudoephedrine vs. phenylephrine 33-year-old... You can buy daily and monthly the most common decongestants phenylephrine in the production! Production of phenylephrine vs pseudoephedrine despite it taking uneconomic quantities to produce meagre yields of methamphetamine tablet or liquid form can! Both pseudoephedrine and phenylephrine are the most common decongestants who takes these drugs be used together it! Pseudoephedrine acts on the label ready to breathe easier, check out this comparison pseudoephedrine. Products are readily available, but federal laws have limited its availability because of its use in Sudafed products risk...
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